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Also called "poor man's cocaine," carries a serious social and health risk for causing dependence and harmful effects it causes in the body.
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Prolonged exposure to cocaine can cause permanent changes in how genes are turned on and off in the brain, a finding that could develop more effective treatments for many types of addictions.
A mouse study conducted by the team of Ian Maze, of Mount Sinai School of Medicine in New York, found that chronic cocaine addiction prevented a specific enzyme to carry out its work of elimination of some genes in the brain’s pleasure circuits.
This effect was eager than rodents more drugs.
The research helps explain how cocaine use changes the brain, said Dr. Nora Volkow, director of the National Institute on Drug Abuse, part of the National Institutes of Health, which funded the study published in the journal Science.
“This discovery is enabling a new understanding of how the repeated use of drugs in the long term modifies the function of neurons,” Volkow said in a telephone interview. (more…)
